Research Use Only
TB-500 is a synthetic peptide related to thymosin beta-4, supplied by Nocap Research strictly as a research chemical for qualified laboratory research use only.
TB-500 is a name used for synthetic peptides related to thymosin beta-4. In the analytical literature it refers to the N-acetylated heptapeptide Ac-LKKTETQ, residues 17 to 23 of thymosin beta-4 (CAS 885340-08-9); some suppliers use it for full-length thymosin beta-4. The independent lab's certificate for the current Nocap Research batch records identity as "TB-4 Confirmed" by HPLC against a reference standard.
The name TB-500 is used in the doping-control and analytical chemistry literature for the synthetic peptide Ac-LKKTETQ, an N-terminally acetylated fragment matching residues 17 to 23 of thymosin beta-4. It is catalogued under CAS registry number 885340-08-9 with molecular formula C38H68N10O14 and a molecular weight of approximately 889.0 g/mol. Thymosin beta-4 itself is a 43-residue polypeptide of the beta-thymosin family. Nocap Research offers this material solely as a reference material for in vitro laboratory investigation, and nothing on this page describes an effect in humans or animals.
| Compound name | TB-500 (thymosin beta-4 fragment 17-23, acetylated) |
|---|---|
| Compound class | Synthetic peptide (research chemical) |
| Amino acid count | 7 |
| Sequence (one-letter) | Ac-LKKTETQ |
| CAS registry number | 885340-08-9 |
| Molecular formula | C38H68N10O14 |
| Molecular weight | Approximately 889.0 g/mol |
| Physical form | Lyophilized powder |
| Intended use | Laboratory research use only |
Published analytical work identified the acetylated 17-23 fragment of thymosin beta-4 as the key component of products sold as TB-500, and later testing of products sold as TB500 and TB1000 found that their contents did not consistently match their labels. In practice the name is attached to more than one material.
That is why the identity result on each batch certificate matters more than the product name. The independent lab confirms identity by comparing the sample's HPLC retention time with a reference standard; for the current Nocap Research batch the certificate records the identity line as "TB-4 Confirmed". The specification table above describes the material the analytical literature calls TB-500, and identity data for full-length thymosin beta-4 is listed here for comparison.
| Compound name | Thymosin beta-4 (INN timbetasin) |
|---|---|
| Amino acid count | 43 (N-terminally acetylated) |
| Sequence (one-letter) | Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES |
| CAS registry number | 77591-33-4 |
| Molecular formula | C212H350N56O78S |
| Molecular weight | Approximately 4963.5 g/mol (calculated) |
The material is supplied as a lyophilized (freeze-dried) powder. As a laboratory reagent, lyophilized peptide is generally stored desiccated and protected from light, with long-term storage commonly at -20C or below and short-term working material at 2C to 8C. For laboratory work the powder is solubilized in a solvent chosen for the intended in vitro application. These notes describe general handling of the material as a research reagent. They are not instructions for use in humans or animals.
Every Nocap Research batch of TB-500 is tested by an independent laboratory before it is listed. The current batch results are below, transcribed from the certificate of analysis. The full certificate, and a link to verify it directly with the lab, are one click away.
| Testing lab | ILS Laboratories |
|---|---|
| Analysis confirmed | August 14, 2026 |
| Purity (HPLC) | 99.44% |
| Measured content | 10.59 mg |
| Test performed | Purity, identity and quantitation (HPLC) |
| Certificate |
View the lot LOT-2026-001, certificate COA-2026-NOHRBM certificate of analysis
Verify this certificate on the ILS Laboratories portal |
How Nocap Research tests every batch and how to read a certificate of analysis.
The peer-reviewed papers below characterize TB-500 at the level of chemistry, structure, synthesis or analytical method. These references describe scientific literature and are not evidence of safety or efficacy for use in humans or animals.
Price, current stock and the batch certificate for TB500 10mg are listed on its product page. An account is required to purchase.
Research use only. Not for human or animal consumption.