Research Use Only
MOTS-c is a synthetic 16-residue peptide supplied by Nocap Research strictly as a research chemical for qualified laboratory research use only.
MOTS-c is a 16-amino-acid peptide with the sequence MRWQEMGYIFYPRKLR, CAS registry number 1627580-64-6, molecular formula C101H152N28O22S2 and a molecular weight of about 2174.6 g/mol. Its name comes from the mitochondrial open reading frame of the 12S rRNA in which it is encoded. Nocap Research supplies a synthetic version for laboratory research only.
MOTS-c, short for mitochondrial open reading frame of the 12S rRNA-c, is a peptide of 16 amino acids with the sequence MRWQEMGYIFYPRKLR. It is catalogued under CAS registry number 1627580-64-6 and is described by the molecular formula C101H152N28O22S2, with a molecular weight of approximately 2174.6 g/mol. The peptide is linear and unmodified, and its two methionine residues account for the sulfur in the formula. Nocap Research offers a synthetic version solely as a reference material for in vitro laboratory investigation, and nothing on this page describes an effect in humans or animals.
| Compound name | MOTS-c |
|---|---|
| Compound class | Synthetic mitochondrial-derived peptide (research chemical) |
| Amino acid count | 16 |
| Sequence (one-letter) | MRWQEMGYIFYPRKLR |
| CAS registry number | 1627580-64-6 |
| Molecular formula | C101H152N28O22S2 |
| Molecular weight | Approximately 2174.6 g/mol |
| Physical form | Lyophilized powder |
| Intended use | Laboratory research use only |
MOTS-c belongs to the class of mitochondrial-derived peptides: short peptides whose coding sequences sit within mitochondrial DNA rather than the nuclear genome. The MOTS-c sequence is encoded within the mitochondrial 12S rRNA gene.
The two methionines (positions 1 and 6) and the tryptophan at position 3 are oxidation-sensitive residues, so storing the lyophilized material desiccated, cold and protected from light is particularly relevant for this sequence.
The material is supplied as a lyophilized (freeze-dried) powder. As a laboratory reagent, lyophilized peptide is generally stored desiccated and protected from light, with long-term storage commonly at -20C or below and short-term working material at 2C to 8C. For laboratory work the powder is solubilized in a solvent chosen for the intended in vitro application. These notes describe general handling of the material as a research reagent. They are not instructions for use in humans or animals.
Every Nocap Research batch of MOTS-c is tested by an independent laboratory before it is listed. The current batch results are below, transcribed from the certificate of analysis. The full certificate, and a link to verify it directly with the lab, are one click away.
| Testing lab | ILS Laboratories |
|---|---|
| Analysis confirmed | August 14, 2026 |
| Purity (HPLC) | 99.75% |
| Measured content | 10.72 mg |
| Test performed | Purity, identity and quantitation (HPLC) |
| Certificate |
View the lot LOT-2026-001, certificate COA-2026-7I--3H certificate of analysis
Verify this certificate on the ILS Laboratories portal |
How Nocap Research tests every batch and how to read a certificate of analysis.
The peer-reviewed papers below characterize MOTS-c at the level of chemistry, structure, synthesis or analytical method. These references describe scientific literature and are not evidence of safety or efficacy for use in humans or animals.
Price, current stock and the batch certificate for MOTS-C 10mg are listed on its product page. An account is required to purchase.
Research use only. Not for human or animal consumption.